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建模瘤微环境的复杂性质:3D瘤球体作为一个不断发展的工具
Daniel B Rodrigues1,2, Rui L Reis1,2, Rogério P Pirraco3,4
13B's Research Group, I3Bs, Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence On Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017, Guimarães, Portugal.
Journal of biomedical science
|January 23, 2024
概括
3D球形模型通过模仿瘤微环境来推进癌症研究,改善了对细胞-细胞和细胞-细胞外基质相互作用的研究,以获得更好的治疗开发.
科学领域:
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
- 细胞生物学 细胞生物学
背景情况:
- 癌症疗法开发面临挑战,因为缺乏准确模拟瘤微环境的平台.
- 越来越多的人从动物模型转向体外3D系统进行更相关的测试.
- 球体正在成为癌症研究的有希望的体外3D模型.
研究的目的:
- 总结关键的细胞相互作用驱动瘤的发展,进展和入侵.
- 为了评估当前的3D球形模型如何回顾这些关键的细胞相互作用.
- 推测未来3D球形模型的进展,用于瘤建模.
主要方法:
- 关于瘤发育中的细胞相互作用的当前文献的综述.
- 分析现有的3D球形模型及其模拟瘤微环境的能力.
- 在球状体内讨论细胞-细胞和细胞-细胞外矩阵相互作用.
主要成果:
- 球形模型已经在复制瘤相关的细胞外基质的生物机械线索方面取得了进展.
- 这些模型越来越多地捕获了细胞-细胞和细胞-细胞外矩阵相互作用的基本特征.
- 目前的球形模型在总结瘤生物学的关键方面表现出有希望.
结论:
- 3D球形模型为研究癌症生物学提供了一个强大的体外平台.
- 持续的开发将增强他们模拟瘤进展和入侵的能力.
- 未来的进展将巩固球体对临床前癌症研究的相关性.
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...