在VATS肺部外科手术期间进行术前肺部保护的胸部副脊椎阻塞:随机临床试验的研究协议
Jiayu Zhu1, Biyu Wei2, Lili Wu1
1Department of Anaesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Trials
|January 23, 2024
概括
胸部副脊椎阻塞 (TPVB) 可以减少视频辅助胸腔镜手术 (VATS) 后的术后肺部并发症 (PPCs). 这项研究调查了TPVB与全身麻醉 (GA) 结合在VATS肺部手术中是否比GA单独提供更好的肺部保护.
科学领域:
- 麻醉学 麻醉学
- 胸部外科手术 胸部外科手术
- 关键护理医学 关键护理医学
背景情况:
- 手术后的肺部并发症 (PPC) 增加了VATS肺部手术后的死亡率和住院时间.
- 胸前副脊椎阻塞 (TPVB) 提供有效的止痛药,但其对PPC的影响尚不清楚.
- 优化术后肺部保护对于VATS程序至关重要.
研究的目的:
- 为了确定TPVB与全身麻醉 (GA) 结合是否减少PPC在VATS肺部手术中.
- 为了评估TPVB与GA单独相比的外科手术期间肺部保护作用.
- 评估与VATS患者TPVB相关的长期预后.
主要方法:
- 302名接受VATS肺部手术的患者随机分配到TPVB或对照组.
- 在GA之前,TPVB组在胸部准脊椎空间接受了15毫升0.5%的罗皮瓦卡因.
- 两组都接受了保护性通风,标准流体管理和患者控制的止痛疗法.
主要成果:
- 主要终点:手术后7天内PPC的复合结果.
- 二级终点:血液气体分析,肺超声波得分,疼痛得分 (NRS),康复质量 (QoR-15) 和住院指标.
- 此外,还将分析长期预后指标.
结论:
- 这项研究将评估TPVB对PPC发病率的影响以及VATS叶切除术/细分切除术的长期结果.
- 结果可能会为加强外科手术期间肺部保护的临床策略提供信息.
- 这项研究旨在提供证据,以优化胸部手术后患者的康复.
相关概念视频
01:27Pneumothorax-II
153
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
153
01:26Endoscopic Studies II: Thoracocentesis
264
Thoracentesis(Thoracocentesis), commonly known as pleural tap, is a medical procedure where a 22 gauge needle is inserted into the pleural space, the area between the lung and chest wall. This procedure is commonly performed to diagnose or treat various respiratory disorders.
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
264
01:30Endoscopic Studies I: Bronchoscopy and Thoracoscopy
201
Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
201