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一种罕见的非加多增强瘤脑转移的罕见非加多增强瘤脑转移,其中的微环境主要由与瘤相关的巨细胞主导

David Rogawski¹, Joshua Wheeler², Esther Nie³

¹Division of Neuro-Oncology, Stanford Medicine, Stanford, CA, 94305, USA. rogawski@stanford.edu.

Acta neuropathologica communications

|January 23, 2024

概括

本病例报告详细介绍了一种罕见的脑转移,由低级纤维肌肉类肉瘤 (LGFMS) 引起,具有独特的成像和病理学. 瘤显示出广泛的瘤相关巨细胞 (TAMs),这表明这种肉瘤脑转移的免疫学冷环境.

科学领域:

神经瘤学神经瘤学
肉瘤研究研究肉瘤研究
免疫学免疫学免疫学

背景情况:

脑转移在肉瘤中很罕见,存活率很低.
低度纤维肌状肉瘤 (LGFMS) 是一种不常见的亚型.
免疫检查点抑制剂 (ICI) 疗法越来越多地用于肉瘤治疗.

研究的目的:

报告一个罕见的LGFMS脑转移病例.
描述独特的放射学和组织病理学特征.
探索瘤脑转移中的瘤微环境.

主要方法:

一个患有LGFMS的患者的病例报告.
放射性成像分析 (MRI).放射性成像分析 (MRI).
解剖组织病理学专注于免疫细胞透.

主要成果:

在15个月内观察到一个单一的,进展的中脑转移.
在放射学上,病变模仿了脱髓化 (非增强性,T2高强度,外周扩散限制).
组织病理学揭示了瘤相关巨细胞 (TAM) 透的密度,特别是在前沿,淋巴细胞很少.

结论:

这一案例突出显示了LGFMS脑转移的不寻常成像特征.
密集的TAM透表明一个免疫抑制瘤微环境.
对TAMs在肉瘤大脑转移中的作用进行进一步研究是有必要的.

关键词:

大脑转移的转移.脑瘤微环境是一个微环境.这种类型的肉瘤是sarcoma.与瘤相关的巨细胞.

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