用于口服配方的类固醇的味道掩饰
Kawther Khalid Ahmed1, Hanan Jalal Kassab1, Intesar Jawad Al Ramahi2
1University of Baghdad, College of Pharmacy, Department of Pharmaceutics, Baghdad, Iraq.
Turkish journal of pharmaceutical sciences
|January 23, 2024
概括
这项研究开发了一种儿童友好的可类固醇片,使用Eudragit固体分散剂进行有效的口味掩饰. 该配方确保了儿童更好的口服接受,解决了口服类固醇的苦味.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 儿科配方 儿科配方 儿科配方
背景情况:
- 口服类固醇经常被处方用于儿科疾病.
- 类固醇固有的苦味对儿童的药物坚持提出了重大挑战.
- 开发可口的剂量形式对于改善治疗结果至关重要.
研究的目的:
- 为了制定一个小儿友好和可口口服的类固醇剂型.
- 为了掩盖德克萨米他和普雷迪尼索隆的苦味,以改善儿科接受度.
- 为了创建一个易于的平板电脑,具有可接受的口感.
主要方法:
- 使用尤德拉吉特,聚乙烯甘醇和带巧克力调味剂的pectin制备德克萨米他固体分散剂.
- 健康志愿者对口味掩饰效率的评估.
- 含有甜味剂的可片的配方和可口性,硬度和指数的评估.
- 使用普得尼索隆的口味掩蔽方法的确认.
主要成果:
- 基于尤德拉吉特的固体分散物有效地掩盖了德克萨米他的苦味.
- 配备40%曼尼托尔的药片表现出可以接受的口感,硬度和特性.
- 味道掩盖策略成功地应用于普雷尼索隆,尽管需要调整载体:药物比率和调味剂 () 以获得最佳的口感.
- 携带者:药物比率和调味剂的选择对于提高药片口味度至关重要.
结论:
- 欧德拉吉特固体分散是一种可行的方法,可以掩盖苦味类固醇的味道.
- 开发的固体分散剂可以制造成可口,易于的儿科友好的可片.
- 优化载体:药物比率和调味剂对于在儿科类固醇配方中实现最大可口度至关重要.
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