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电解质复合维生素和尼奥米辛对运输羊羔免疫力和肠道屏障功能的影响

Cui Xia^1,2, Chunhui Duan¹, Conghui Chen¹

¹College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071001, China.

Animals : an open access journal from MDPI

|January 23, 2024

概括

电解复合维生素在运输压力期间显著改善了羊羔免疫力和肠道屏障功能. 这种食补充剂在提高羔羊健康和肠道完整性方面显示出比neomycin更好的结果.

科学领域:

动物科学动物科学
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

运输会给动物带来很大的压力,影响生理和免疫学参数.
了解减轻压力和支持运输期间动物福利的干预措施对于畜牧管理至关重要.

研究的目的:

为了评估一个电解复合维生素与neomycin相比在减轻羊羔的运输压力的有效性.
评估这些补充剂对生长,免疫反应和肠道屏障功能的影响.

主要方法:

60只4个月大的羔羊被分为三个组:对照组 (基础饮食),电解复合维生素 (375毫克/天/羔羊) 和neomycin (200毫克/天/羔羊).
测量包括体重,血清免疫球蛋白 (IgA,IgG),压力激素 (ACTH,E,COR),细胞因子 (IL-1β,IL-6,IFN-γ),结肠发酵产物,肠道形态,以及屏障和炎症标记的基因/蛋白质表达.
与运输日相比,采样时间为0,7日和14日.

主要成果:

综合维生素和新米素组都显示了羊肉体重,IgA和IgG的增加,压力激素和促炎细胞因子的减少.
多种维生素组表现出增强的结肠酸盐,改善的阴茎和结肠形态 (维卢斯高度,V / C比率,密室深度) 和升调的肠壁蛋白 (Occludin,MUC1,ZO-1).
在补充剂的两组中,炎症信号通路 (TRAF6,TLR4,MyD88,NF-kB) 降低了调节,在多维生素组中观察到更显著的减少.

结论:

电解复合维生素补充剂有效地改善了运输压力下的羊羔的免疫力和肠道屏障功能.
电解复合维生素的剂量为375mg/天,在减轻压力和改善肠道健康方面,与neomycin相比,其疗效更高.
用电解复合维生素补充饮食是一种有前途的策略,可以改善牲畜运输期间的动物福利和表现.

关键词:

电解式多种维生素的多种维生素免疫功能免疫功能免疫功能肠道健康肠道健康羊羔羊羔羊羔羊羔这是一种neomycin.运输压力运输压力

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