小麦聚醇通过抑制MAPK/NF-κB炎症体通路和调节肠道微生物群来改善小鼠DSS诱导的性结肠炎
Xusheng Wen1, Han Peng2, Hua Zhang3
1State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China.
Foods (Basel, Switzerland)
|January 23, 2024
概括
小麦聚醇 (WBP) 在性结肠炎 (UC) 的小鼠模型中有效降低了结肠炎症. 通过调节微生物群和抑制炎症途径,WBP改善了肠道健康.
科学领域:
- 生物化学 生化学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 小麦 (WB) 富含生物活性多.
- 性结肠炎 (UC) 是一种慢性炎症性肠病.
- 为UC管理探索饮食干预措施.
研究的目的:
- 为了分析小麦多 (WBP).
- 研究WBP对小鼠中硫酸 (DSS) 诱导的大肠炎的治疗效果.
- 阐明WBP行动的基本机制.
主要方法:
- 对WB的定性和定量多醇分析.
- 在小鼠中的DSS诱导性结肠炎模型.
- 评估结肠形态,炎症性细胞因子 (IL-10,TNF-α,IL-6,IL-1β),MAPK/NF-κB通路激活,以及肠道微生物群组成.
主要成果:
- 主要WBP成分被确定为酸 (香草酸,酸,咖啡酸,酸,原卡特丘酸).
- WBP显著降低了结肠炎的严重程度,改善了结肠形态.
- 通过对IL-10进行上调和对TNF-α,IL-6,IL-1β进行下调,WBP抑制了炎症.
- WBP抑制了MAPK/NF-κB通路的激活.
- WBP调节了肠道微生物群,增加了Firmicutes/Bacteroidetes的比率,并改变了特定的品种.
结论:
- 小麦的多表明对实验性结肠炎有显著的保护作用.
- 通过减少炎症,调节肠道微生物群,并抑制关键信号通路,WBP改善UC.
- WBP显示为治疗性结肠炎的功能性食品成分具有前途.
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
334
01:29Drugs for Treatment of Ulcerative Colitis in IBD
142
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
142
01:17Drugs for Treatment of Diarrhea-Predominant IBS
176
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
176
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
187
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
187
01:17Chronic Bowel Disorders: Introduction
455
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
455
01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
430
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
430