血清中与年龄相关的变化-男性和女性的葡萄糖含量-与并发症相关的集群
Óscar Lado-Baleato1,2, Jorge Torre1, Róisín O'Flaherty3,4
1Research Methodology Group, Health Research Institute of Santiago de Compostela (IDIS), Galician Health Service, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
Biomolecules
|January 23, 2024
概括
血清N-葡萄糖的模式随着年龄和性别的变化而变化,这可能表明不健康的衰老. 这些甘氨酸的特征与老年人患病并发症和炎症的增加有关.
科学领域:
- 格莱科米克斯 (Glycomics) 是一个有趣的药物.
- 衰老研究研究 衰老研究
- 代谢学 代谢学 代谢学
背景情况:
- 人体血清N-葡萄糖,一个复杂的N-链 glycans的配置文件,经历了随着年龄的变化.
- 了解这些与年龄相关的糖质变化及其与健康状况的关联对于识别衰老生物标志物至关重要.
研究的目的:
- 针对年龄和性别的一般成年人群的血清N-葡萄糖的特征.
- 调查血清N-葡萄糖的模式和与年龄相关的并发症之间的关联.
主要方法:
- 在1516名成年人中,使用水友交互色谱与超高性能液体色谱 (HILIC-UPLC) 进行血清N-葡萄糖组分析.
- 主要成分分析和K-媒介聚类以确定甘氨酸模式和组个体.
- 分析生活方式因素,代谢障碍,炎症标志物和并发症指数作为共同变量.
主要成果:
- 在个别的N-甘氨酸峰值和甘氨酸特征 (分支,化等) 中观察到与年龄和性别相关的显著差异. ) 的情况.
- 两种不同的N-糖集群出现了:一个具有更简单的N-糖,另一个具有更高阶的N-糖.
- 与年龄较大相关的更简单的N-glycan集群表现出更高的葡萄糖,糖化标志物,炎症标志物,较低的淋巴细胞过率和更大的并发症.
结论:
- 血清N-葡萄糖表现出特定于年龄和性别的变化.
- N-糖体模式可能作为不健康衰老的生物标志物,与发炎假说保持一致.
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