系统和局部策略用于乳腺癌的初级预防
Erin K Zaluzec1,2, Lorenzo F Sempere1,3
1Precision Health Program, Michigan State University, East Lansing, MI 48824, USA.
Cancers
|January 23, 2024
概括
针对高风险女性,正在制定新的乳腺癌预防策略. 这些创新方法旨在降低癌症风险,并且副作用比手术或荷尔蒙疗法等当前选择少.
科学领域:
- 在瘤学瘤学.
- 预防医学 预防医学
- 遗传学 遗传学 是一个
背景情况:
- 乳腺癌影响美国8分之一的女性.
- 对于中度风险女性 (12.5-20%) 存在有限的风险降低选择.
- 高风险女性 (>20%),包括BRCA突变携带者,面临着有限的初级预防选择,主要是手术或抗雌激素治疗.
研究的目的:
- 对初级乳腺癌预防的创新研究策略进行审查和讨论.
- 突出需要新的干预措施与最小的副作用.
- 探索对高风险和低风险人群的潜在应用.
主要方法:
- 对当前和新兴的乳腺癌初级预防策略进行了广泛的审查.
- 讨论研究方法,包括临床前和临床试验阶段的方法.
- 分析新型风险降低方法的潜在好处和局限性.
主要成果:
- 大多数新的策略都处于临床前阶段.
- 一些研究策略目前正在临床试验中.
- 在五年内,预计将有几种新策略进行首次人体试验.
结论:
- 有必要改善关于现有的乳腺癌风险降低策略的沟通.
- 开发新的,耐受性良好的初级预防方法至关重要.
- 最初针对高风险个体的研究策略,如果被证明是有效和安全的,最终可能会使更广泛的人群受益.
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