目前治疗的概念,对于腹部外的desmoid类型纤维化:一个叙事审查
Yong-Suk Lee1, Min Wook Joo2, Seung-Han Shin3
1Department of Orthopaedic Surgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 56 Dongsu-ro, Bupyeong-gu, Incheon 21431, Republic of Korea.
Cancers
|January 23, 2024
概括
额外腹部的desmoid类型纤维素瘤 (EADTF) 治疗已经从手术转向积极监测或全身疗法. 这种罕见的瘤需要谨慎的管理,通常涉及局部控制的非手术选择.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 额外腹部脱类型纤维素瘤 (EADTF) 呈现为一种罕见的,局部具有攻击性的纤维细胞瘤.
- 由于EADTF的透性和在手术后复发的倾向,这给临床带来了重大挑战.
研究的目的:
- 审查当前治疗额外腹部desmoid型纤维化症的治疗策略.
- 评估手术与非手术干预的不断变化的作用.
主要方法:
- 在Cochrane图书馆,MEDLINE (PubMed) 和EMBASE数据库中进行了全面的文献搜索.
- 该审查涵盖了从2008年1月到2023年2月发表的文章.
主要成果:
- 手术干预不再是主要的方法;积极监测和全身疗法现在是首选的初始选择.
- 建议对大多数EADTF病例进行6-12个月的积极监测,接受一些进展.
- 非手术方法如辐射,冷,氨酸激酶抑制剂和低剂量化疗是局部控制和全身治疗的关键.
结论:
- 目前EADTF的管理模式强调非手术策略,包括监测和有针对性的全身疗法.
- 不建议进行激素治疗;NSAID用于症状管理.
- 治疗决策应考虑瘤的位置和接近重要结构.
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