对于复发性 Vulvar 癌症的盆腔排泄:一个回顾性研究
Sabrina Classen-von Spee1, Saher Baransi1, Nando Fix1
1Department of Gynecology and Obstetrics, Florence-Nightingale-Hospital, Kreuzbergstraße 79, 40489 Düsseldorf, Germany.
Cancers
|January 23, 2024
概括
盆腔排骨 (PE) 为精选的复发性癌患者提供了更好的生存期. 实现完整的细胞减少和避免远程转移显著影响长期结果,可接受的发病率.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 妇科瘤学 妇科瘤学
背景情况:
- 盆腔排骨 (PE) 是一项具有历史高风险的激进手术.
- 患者选择和术后护理方面的进步改善了结果.
- 复发性癌在临床治疗中具有挑战性.
研究的目的:
- 为了评估患者在复发性癌的骨盆排骨后的结果.
- 确定影响PE后生存的临床和组织病理因素.
- 在这个患者队列中评估与此程序相关的发病率.
主要方法:
- 对17名复发性癌患者的回顾性分析,这些患者在2007年至2022年期间接受了PE.
- 数据收集包括患者人口统计,手术细节,组织病理学和生存率.
- 统计分析以确定影响整体存活时间 (OS) 的因素.
主要成果:
- 患者的中位年龄为64.9岁 (范围为41-81岁).
- 平均整体存活时间为55.7个月,最高为164个月.
- 完整的细胞减少 (p=0.02),治愈性手术指示,以及没有远程转移 (p=0.01) 显著改善了OS. 淋巴转移显示了一个趋势 (p=0.11).
- 35%的患者出现了严重的并发症.
结论:
- 盆腔化是针对复发性癌的选定患者的一种可行的治疗选择.
- 积极的外科边缘和远程转移的缺乏对于有利的长期存活至关重要.
- 在这种专门的瘤环境中,PE提供了良好的生存率和可控的发病率.
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