长非编码RNA作为针对乳腺癌干细胞和瘤免疫微环境的调节剂:生物特性和治疗潜力
Fang Yang1,2, Yiqi Yang1,2, Yuling Qiu1,2
1The Comprehensive Cancer Center of Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Cancers
|January 23, 2024
概括
乳腺癌干细胞 (BCSCs) 驱动瘤的生长和复发. 长非编码RNAs (lncRNAs) 调节BCSCs和瘤免疫微环境 (TIME),为乳腺癌免疫疗法提供潜在的治疗点.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 乳腺癌干细胞 (BCSCs) 具有自我更新和分化能力,有助于瘤异质性,侵略性行为和复发.
- 癌症干细胞性越来越多地与抑制的抗癌免疫力和冷瘤免疫微环境 (TIME) 的发展有关.
- 长非编码RNAs (lncRNAs) 正在成为乳腺癌中干性和免疫反应的关键调节者.
研究的目的:
- 审查lncRNAs在调节乳腺癌干细胞 (BCSCs) 中的多方面的作用.
- 探索lncRNAs,BCSCs和瘤免疫微环境 (TIME) 之间的复杂关系.
- 讨论 lncRNAs 在乳腺癌免疫治疗中作为生物标志物或治疗剂的潜在临床应用.
主要方法:
- 文献综述侧重于研究乳腺癌中的lncRNAs,BCSCs和TIME的研究.
- 对关键途径和分子机制的分析,这些关键途径和分子机制是IncRNA介导的干性和免疫调节的基础.
- 综合目前关于lncRNAs在乳腺癌治疗中的临床相关性的证据.
主要成果:
- lncRNAs显著影响BCSC的特性,包括自我更新,分化和瘤性.
- lncRNAs的调节失调通过调节 TIME 来促进免疫逃逸,往往促进"寒冷"或非免疫原性状态.
- 特定的lncRNA与乳腺癌的进展和免疫治疗的反应有关,例如PD-1/PD-L1抑制剂.
结论:
- lncRNAs是乳腺癌干细胞和瘤免疫微环境的关键调节者.
- 针对lncRNAs有望克服免疫治疗的耐药性,并改善乳腺癌的治疗结果.
- 对lncRNA功能的进一步研究可能会导致新的诊断生物标志物和乳腺癌的治疗策略.
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