结肠直肠癌的非治愈性治疗选择:预测因素和丹麦的医院间变化:基于人口的注册研究
Søren Rattenborg1,2,3, Torben Frøstrup Hansen2,3,4, Sören Möller5,6
1Department of Surgery, Vejle Hospital, University Hospital of Southern Denmark, Beriderbakken 4, 7100 Vejle, Denmark.
Cancers
|January 23, 2024
概括
非治愈性结直肠癌 (CRC) 治疗和辅助化疗决策的预测因素包括年龄,表现状况和疾病因素. 医院存在显著的差异,需要进一步调查.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 在结直肠癌 (CRC) 中观察到治疗变化.
- 国家建议指导CRC治疗方案.
- 了解影响治疗决策的因素至关重要.
研究的目的:
- 为了确定潜在可治愈的结直肠癌中非治愈性治疗的预测因素.
- 调查与不接受辅助化疗相关的因素.
- 分析这些治疗决策的医院间变化.
主要方法:
- 基于注册的研究包括34116名CRC患者 (2009-2018).
- 后勤回归分析以确定预测因素.
- 包括患者,疾病,社会经济和外科手术期间的因素.
主要成果:
- 非治愈治疗的预测因素:高年龄,表现不佳,远程转移,体重不足.
- 没有辅助化疗的预测因素:高年龄,表现不佳,脏疾病,术后并发症,独自生活.
- 对于这两种结果,观察到医院间的显著差异.
结论:
- 非治愈性治疗和保留辅助化疗与已知的危险因素有关,另外分别是体重不足和独自生活.
- 医院之间存在治疗决策的显著差异.
- 建议对这些医院变异进行进一步检查.
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