患有急性淋巴细胞和急性髓母细胞白血病的儿童的铁过载 - - 一个中心的经验
Malgorzata Sawicka-Zukowska1, Anna Kretowska-Grunwald1,2, Agnieszka Kania1
1Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Jerzego Waszyngtona 17, 15-274 Bialystok, Poland.
Cancers
|January 23, 2024
概括
患有白血病的儿童血清费里水平升高表明癌症生长和输血导致的铁过载. 在癌症治疗期间,对费里丁的监测至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 临床化学 临床化学
背景情况:
- 包装红细胞 (PRBC) 输血对于治疗急性淋巴细胞白血病 (ALL) 和急性髓母细胞白血病 (AML) 等儿科癌症至关重要.
- 这些输血虽然可以挽救生命,但可能导致铁过载,这是长期癌症护理的一个重大问题.
研究的目的:
- 调查血清费里丁 (SF) 作为白血病生长标志物的作用.
- 评估SF作为输血相关铁过载的指标在儿童白血病患者.
主要方法:
- 对135名接受ALL或AML治疗的儿童进行了纵向研究.
- 在整个治疗期间,血清费里丁水平,PRBC输血史,年龄和体重都被监测.
主要成果:
- 在诊断时,41%的患者超过了500 ng/mL的SF水平,在停止治疗后增加到80%.
- 治疗结束时观察到SF显著增加,特别是在急性髓母细胞白血病 (AML) 患者中,这些患者也接受了更多的输血.
- 在SF水平与患者年龄,体重和输血的PRBC单位数量之间发现了积极的相关性.
结论:
- 血清费里作为一种有用的,尽管不特定的,白血病活动标记.
- 儿科白血病患者的SF水平升高与PRBC输血导致的铁过载密切相关,无论白血病亚型如何.
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