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Updated: Jul 5, 2025

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
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下一代CEA-CAR-NK-92细胞对抗固体瘤:克服结直肠癌中的瘤微环境挑战

Alexander Sebastian Franzén1,2, Abdelhadi Boulifa1,2, Clarissa Radecke2

  • 1Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Cancers
|January 23, 2024
PubMed
概括

一种新的化学抗原受体 (CAR) 自然杀手 (NK) 细胞疗法针对结直肠癌 (CRC) 中的细胞相关癌胚抗原 (CEA). 这种工程化CAR-NK-92细胞疗法表现出强大的抗瘤活性和增强的瘤透,没有兄弟杀伤.

关键词:
3D瘤模型 3D瘤模型这是CAR-NK.CCR4 CCR4 CCR4 CCR4 CCR4 CCR4 CCR4 CCR4 CCR4 CCR4 CCR4 CCR4 CCR4 CCR4在 CEA CEA 中.在NK-92细胞系中,NK-92细胞系的细胞系在PD1检查点抑制 (CPI) 过程中.大肠直肠癌 (CRC) 是一种癌症.免疫疗法 免疫疗法输血细胞形成的过程瘤微环境是一个微环境.

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