早期结肠直肠癌的多民族趋势
Michelle Nagata1, Kohei Miyagi1, Brenda Y Hernandez1
1Population Sciences in the Pacific Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA.
Cancers
|January 23, 2024
概括
早期结肠直肠癌 (EOCRC) 不成比例地影响夏威夷原住民,诊断比其他族群早5-10年. 在夏威夷,EOCRC的发病率在女性中比男性上升得更快.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 有限的数据存在于美国的亚洲和原住民夏威夷人群的早期结直肠癌 (EOCRC).
- 以前的研究主要集中在白人,非裔美国人和西班牙裔人口统计学上.
- 了解不同种族群体的EOCRC趋势对于有针对性的健康干预至关重要.
研究的目的:
- 为了检查夏威夷多民族人口中EOCRC的当前特征.
- 为了确定EOCRC发病率,死亡率和存活率的种族和性别特异性趋势.
- 为了比较夏威夷不同种族群体的EOCRC介绍和结果.
主要方法:
- 利用了来自夏威夷瘤登记处的数据,用于2000-2019年间诊断的结直肠癌 (CRC) 病例.
- 分析了CRC病例的亚部位,年龄,性别,种族和阶段.
- 评估发病率,死亡率和生存率,使用年龄调整率和统计比较.
主要成果:
- 整体CRC发病率和死亡率下降,结肠癌的下降幅度大于直肠癌/直肠肌瘤癌.
- 在45岁以下的人群中,结肠癌的发病率显著增加,而在45-54岁的人群中,直肠/直肠结肠癌的发病率增加.
- 与其他族群相比,夏威夷原住民在5-10年前被诊断出来,CRC死亡率更高,生存率更低.
- 在夏威夷,EOCRC的发病率在女性中比男性增加得更快,与国家趋势不同.
结论:
- 原住民夏威夷人不成比例地经历EOCRC,在年轻时呈现较差的结果.
- 夏威夷女性中EOCRC率的增加凸显了独特的种族和性别特异性差异.
- 对种族特异性风险因素和针对EOCRC的有针对性的干预措施进行进一步的研究是有必要的.
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