母亲饮食和身体活动对子女表观基因组的影响
Anastasia Panagiotidou1, Christos Chatzakis1,2, Athina Ververi1,3
1School of Medicine, Aristotle University of Thessaloniki, 546 22 Thessaloniki, Greece.
Genes
|January 23, 2024
概括
孕妇的生活方式干预,如怀孕期间的饮食和运动,可能会导致后代的表观基因组发生微妙的变化,影响与新陈代谢和生长相关的基因. 需要更多的研究来证实这些影响.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 孕产妇健康 孕产妇健康
- 发展生物学 发展生物学
背景情况:
- 母亲表观基因组在胎儿发育中起着至关重要的作用.
- 怀孕期间的生活方式因素会影响后代的健康状况.
- 了解表观遗传修饰提供了对长期健康轨迹的洞察.
研究的目的:
- 审查关于母亲生活方式干预和它们对后代表观基因组的影响的现有文献.
- 综合了随机对照试验 (RCT) 调查饮食和体力活动干预措施的研究结果.
- 为了识别受这些干预影响的特定表观遗传标记 (DNA甲基化,miRNA表达,基因组修饰).
主要方法:
- 在PubMed,Scopus和Cochrane-CENTRAL的系统文献搜索到2023年7月.
- 包括将生活方式干预措施与标准护理进行比较的RCT.
- 研究结果的定性分析,重点关注DNA甲基化,miRNA表达和基因素修饰.
- 评估了7项涉及1765对母亲和孩子的研究.
主要成果:
- 母亲的饮食和体育活动干预与胎儿组织 (带血,胎盘) 的DNA甲基化和miRNA表达的轻微改变有关.
- 受影响的基因组区域与脂肪,代谢过程,2型糖尿病,出生体重和生长有关.
- 并非所有研究都报告了DNA甲基化在统计学上显著的变化,这表明发现的变化.
结论:
- 在怀孕期间,母亲的生活方式干预显示出诱导后代微妙表观遗传修饰的潜力.
- 观察到的表观遗传变化与关键的发育和代谢途径有关.
- 需要进一步进行高质量的标准化研究来证实这些发现,并阐明这些表观遗传变化的生物学意义.
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