比利时特维伦的异形性风险等位基因趋势:一个纵向遗传分析
Nathan Kinsey1, Janelle M Belanger1, Paul J J Mandigers2
1Department of Animal Science, University of California, Davis, CA 95616, USA.
Genes
|January 23, 2024
概括
比利时特维伦犬的异形是遗传的. 尽管人们意识到这一点,但对CFA37的IE风险等位基因进行育种选择并未成功,因而等位基因频率在未受影响的狗中增加,而在受影响的狗中减少.
科学领域:
- 兽医遗传学 兽医遗传学
- 狗的健康 狗的健康
- 的研究研究.
背景情况:
- 异常性 (IE) 是比利时特鲁伦犬的一种已知的遗传性疾病.
- 最近的研究在Canis familiaris染色体 (CFA) 14和37上确定了IE的风险基因型.
研究的目的:
- 分析比利时Tervuren的IE风险位点的等位基频率.
- 为了确定育种者是否有意在一段时间内针对IE进行了选择.
- 评估选择对IE在品种中的有效性.
主要方法:
- 比较比利时Tervuren的两个世代分组之间的等位基因频率.
- 对CFA14和CFA37.7上风险相关基因的分析.
- 随着时间的推移 (1985-2015年) 对等位基因频率变化的统计分析.
主要成果:
- 在CFA14上与风险相关的等位基因的基因频率在1985年至2015年期间保持不变.
- 在对照群体中,CFA37上与风险相关的等位基因的等位基因频率增加 (p < 0.05).
- 患有IE的狗在CFA37位点 (p <0.05) 显示IE风险相关等位基频率下降 (p <0.05).
结论:
- 比利时特鲁文的IE的选择并没有成功.
- 这种品种的发作患病率似乎在增加.
- 导致IE的遗传因素需要进一步调查和有针对性的育种策略.
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