儿童在出院时未经许可/非标签的药物处方:使用例行收集的健康数据进行的一项观察性研究
Elham Jaberi1, Inesse Boussaha2, Xavier Dode3
1UMR CNRS 5558, Laboratoire de Biométrie et Biologie Humaine, Équipe Évaluation et Modélisation des Effets Thérapeutiques, rue Guillaume-Paradin, BP8071, CEDEX 08, F-69376 Lyon, France.
Healthcare (Basel, Switzerland)
|January 23, 2024
概括
在法国,近40%的儿科医院出院处方是未经许可或非标签的 (UL/OL). 年龄较小的儿童和服用更多药物的儿童更有可能获得UL/OL处方,增加与药物有关的问题风险.
科学领域:
- 儿科药理学 儿科药理学
- 药品安全 药品安全
- 健康 结果 研究 研究 结果
背景情况:
- 非许可和非标签 (UL/OL) 处方与与药物有关的问题增加有关.
- 关于UL/OL药物使用在医院出院时的流行情况的数据有限.
- 这项研究解决了了解儿科患者在出院后的UL/OL处方模式的差距.
研究的目的:
- 确定儿童医院出院时门诊处方中未经许可和非标签 (UL/OL) 药物的流行情况.
- 确定与儿童的UL/OL处方相关的特征和预测因素.
主要方法:
- 从儿科医院出院 (2014-2016) 收集的健康数据的回顾性分析.
- 使用法国行业独立的表单Thériaque (产品特征摘要) 来定义许可标签.
- 描述了UL/OL处方特征和分析的预测因素.
主要成果:
- 分析了来自479名儿童的2536份处方.
- 非标签 (OL) 处方为39.2%,未经许可 (UL) 处方为2.3%,其中74%的儿童至少服用了一种UL/OL药物.
- 年龄较小和处方药数量较多是UL/OL处方的重要预测因素.
结论:
- 在法国,大约40%的儿科医院出院处方涉及未经许可或非标签 (UL/OL) 药物.
- 患病率高凸显了潜在的风险,以及在儿科药物治疗中需要仔细监测的需要.
- 年龄较小的儿童和使用多种药物的儿童代表了UL/OL处方的脆弱群体.
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