自克林IGF-II相关的癌症:从一个罕见的副瘤事件到恶性瘤的标志
Pierluigi Scalia1, Ignazio R Marino2, Salvatore Asero1,3
1The ISOPROG-Somatolink EPFP Research Network, Philadelphia, PA 19102, USA; 93100 Caltanissetta, Italy.
Biomedicines
|January 23, 2024
概括
胰岛素样生长因子II (IGF-II) 在癌症中起到比以前想象的更广泛的作用,作为恶性生长的标志. 这项研究建议重新命名IGF-II分泌瘤 (IGF-IIIsT),以反映其在癌症中超出低血糖的常见作用.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 非小岛细胞瘤低血糖症 (NICTH) 和胰腺外瘤低血糖症 (EPTH) 是与癌症分泌的胰岛素样生长因子II (IGF-II) 相关的副瘤综合征.
- 新兴的分子和细胞发现表明,IGF-II在癌症生物学上具有更广泛的作用,超出了帕拉尼瘤性低血糖症.
- 关键的瘤发生事件包括胎儿胰岛素受体异型 (IR A) 和高分子量IGF-II变体 (大-IGF-II) 的增加,以及自身隐性IGF-II信号的逐渐增加.
研究的目的:
- 重新评估IGF-II表达和分泌在各种癌症中的患病率和重要性.
- 为具有IGF-II分泌特征的瘤提出一个新的功能分类.
- 为开发针对IGF-II产生癌症的向治疗策略提供框架.
主要方法:
- 对外科和临床报告的回顾性分析.
- 对来自患者的癌症细胞系的公开可用的表达数据的分析.
- 关于癌症IGF-II信号通路的文献综述.
主要成果:
- 固体瘤中,尤其是晚期恶性瘤中,IGF-II的表达和分泌比以前认为的更为常见.
- IGF-II经常与癌细胞内的自身隐性信号循环有关,有助于恶性生长.
- IGF-I的促进癌症效应更可能与瘤微环境中的副质信号联系在一起.
结论:
- 自克林IGF-II循环被认为是恶性癌症生长的标志.
- 建议将IGF-II分泌瘤 (IGF-IIIsT) 术语用于涵盖IGF-II在癌症中的更广泛作用.
- 这一重新分类旨在改善治疗策略和针对更广泛的IGF-II产生癌症的个性化干预措施.
关键词:
这就是EPTHTH.在HRA/B的基础上.在IGF-I-IGF-II (蛋白质) 中.国际海事基金-国际海事基金 (IGF-IR) 是一个国际海事基金.在IGF1-IGF2 (基因) 中.在IGF2ST中,我们可以在IGF2oma.爱尔兰国家旅游局 (IRA)什么都没有,什么都没有.这是NSILALA.在 SpI2-6/IGF-IIRR 中.更多相关视频
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