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大脑可塑性调节器p75神经营养受体在不同急性脑损伤后的人类尿液中-一个前性队列研究

Santtu Hellström^1,2, Antti Sajanti¹, Abhinav Srinath³

¹Department of Neurosurgery, Division of Clinical Neurosciences, Turku University Hospital, University of Turku, P.O. Box 52, Hämeentie 11, 20521 Turku, Finland.

|January 23, 2024

概括

晚期尿路p75神经质受体 (p75NTR) 水平可以预测急性脑损伤 (ABIs) 的不利结果. 较晚样本中的较高度表明预后较差,这表明p75NTR是ABI的潜在预后生物标志物.

科学领域:

神经科学是一个神经科学.
生物标志物发现发现
临床神经学临床神经学

背景情况:

急性脑损伤 (ABI) 是一个重大的全球健康挑战.
有效的预后指标对于管理ABI患者的结果至关重要.
尿路p75神经受体 (p75NTR) 作为一种潜在的生物标志物被探索.

研究的目的:

研究尿液p75NTR度作为急性脑损伤患者预后生物标志物.
用修改的兰金表 (mRS) 来比较有利和不利结果之间的p75NTR水平.
评估p75NTR在区分ABI患者与健康对照中的诊断潜力.

主要方法:

收集了46名ABI患者 (动脉瘤下关节出血,缺血性中风,创伤性脑损伤) 和4名健康对照者的尿样.
使用ELISA测量尿中的p75NTR水平,以肌素正常化,在入院后的早期和晚期时间点.
对患者结局 (mRS) 分析了p75NTR度,并将ABI患者与对照进行了比较.

主要成果:

晚期尿液p75NTR度在不良结局的患者中显著更高 (p=0.033),预后准确率为70.9%.
结果组之间没有观察到早期p75NTR水平的显著差异.
与健康对照组相比,ABI患者的尿液p75NTR水平显著升高 (p<0.0001).

结论:

晚期尿液p75NTR度是急性脑损伤不良结果的潜在预后生物标志物.
对于p75NTR的预后值似乎取决于时间,而晚期的测量更有指示性.
需要在更大的队列中进行进一步的研究,以验证p75NTR作为ABI可靠的预后和诊断生物标志物.

关键词:

脑损伤是因为脑损伤.这些神经营养素是神经营养素 (neurotrophins).结果结果结果结果.收回回收回收的恢复一次性中风中风中风中风中风创伤的创伤创伤的创伤.

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