在结肠直肠癌中围和内芽之间的比较
Jung-Soo Pyo1, Ji Eun Choi2, Nae Yu Kim3
1Department of Pathology, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu-si 11759, Republic of Korea.
Biomedicines
|January 23, 2024
概括
瘤芽 (TB),包括周芽 (PTB) 和内芽 (ITB),与侵袭性结直肠癌有关. 根据高PTB/ITB或低PTB/ITB的组合对患者进行分层,可以提高预后准确性.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 癌症研究 癌症研究
背景情况:
- 瘤芽 (TB) 是结肠直肠癌 (CRC) 的预后指标.
- 根据位置,结核病被分为周围芽 (PTB) 或内芽 (ITB).
- 在CRC中结合PTB和ITB的关系和预后意义需要进一步调查.
研究的目的:
- 评估结直肠癌 (CRC) 中PTB和ITB之间的关系.
- 评估PTB和ITB不同组合的临床病理和预后意义.
- 为了确定基于组合或单个高/低PTB和ITB的患者分层是否会影响预后.
主要方法:
- 结肠直肠癌 (CRC) 样本被分析为周围芽 (PTB) 和内芽 (ITB).
- 患者被分为高PTB/ITB,高PTB或ITB和低PTB/ITB类别.
- 在定义的结核病组中比较了临床病理特征和生存结果 (整体和无复发).
主要成果:
- 瘤芽 (TB) 与晚期瘤阶段,淋巴结转移和远程转移有显著的相关性.
- 在高周芽 (PTB) 和高内芽 (ITB) 之间观察到显著的正相关性 (p = 0.010).
- 患有高PTB和高ITB的患者在两种位置都表现出更糟糕的生存结果,而那些只有一种高芽或低芽的患者则表现出更糟糕的生存结果.
结论:
- 瘤芽 (TB) 的存在,无论其位置 (PTB或ITB),都与瘤的攻击性行为和结直肠癌的更差预后有关.
- 根据高PTB和ITB的联合存在与孤立的高芽或低芽患者的分层患者提供了精细的预后评估.
- 对PTB和ITB相互作用的进一步研究可能会提高结直肠癌患者的风险分层和治疗策略.
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