系统性炎症指数的预测和诊断值在支气管肺发育不良症
Linxia Cao1, Xiangye Liu1, Tingting Sun1
1Department of Neonatology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, China.
Children (Basel, Switzerland)
|January 23, 2024
概括
系统性炎症指数,如中性粒细胞与淋巴细胞的比率 (NLR),显示了预测和诊断价值的支气管肺功能障碍 (BPD) 在早产婴儿. 这些标志物可以帮助管理高风险婴儿,改善这种常见呼吸道并发症的结果.
科学领域:
- 新生儿科学 新生儿科学
- 儿科呼吸系统医学 儿科呼吸系统医学
- 炎症和免疫学 炎症和免疫学
背景情况:
- 支气管肺功能障碍 (BPD) 是早产婴儿中最常见的呼吸道并发症,经常出现诊断延迟.
- 炎症在BPD的发病过程中起着至关重要的作用.
研究的目的:
- 评估系统性炎症指数对早产婴儿BPD的预测和诊断能力.
- 确定特定的炎症标志物,可以帮助早期检测和管理BPD.
主要方法:
- 对122名早产婴儿 (<32周妊娠年龄) 的临床数据的回顾性分析.
- 根据NICHD 2018标准将其分为非BPD (n=72) 和BPD (n=50) 组.
- 系统性炎症指数 (包括NLR) 在不同时间点的比较和逻辑回归用于风险因素识别.
主要成果:
- 强迫症的独立风险因素包括出生时体重较低,对于妊娠年龄来说小,以及氧气治疗持续时间较长.
- 在BPD婴儿中,在月经后72小时,1周,3周和36周的月经后年龄 (PMA) 观察到中性粒细胞数 (N),中性粒细胞与淋巴细胞比率 (NLR),单细胞与淋巴细胞比率 (MLR) 和全身炎症反应指数 (SIRI) 的升高.
- 产后3周的NLR显示出最高的预测能力 (AUC 0.717),具有56%的灵敏度和86.1%的特异性;36周的NLRPMA也显示出诊断值 (AUC 0.693).
结论:
- 特定的全身炎症指数,包括N,NLR和SIRI,具有预测和诊断价值,用于预产后3周和36周PMA的早产婴儿的BPD.
- 这些炎症标志物可能会支持高风险患BPD的早产婴儿的治疗策略.
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