聚合体作为下一代具有吸引力的药物输送系统:定义,合成和应用
Mariana Fonseca1, Ivana Jarak1,2, Francis Victor3
1Univ. Coimbra, Laboratory of Drug Development and Technologies, Faculty of Pharmacy, 3000-548 Coimbra, Portugal.
Materials (Basel, Switzerland)
|January 23, 2024
概括
聚合体,来自块共聚物的多功能纳米颗粒,为改善治疗提供先进的药物输送. 监管途径中的挑战阻碍了它们的临床转化.
科学领域:
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 聚合体是自组装的纳米颗粒,来自双胞胎块共聚合物.
- 它们可以封装水友和疏水分子,具有可调节的特性,用于各种应用.
- 现有的疗法在稳定性,有效性和安全性方面面临挑战,需要先进的输送系统.
研究的目的:
- 审查聚合体的制备方法,类型和应用.
- 突出聚合体在增强药物输送方面的潜力,特别是用于化疗,免疫疗法和生物制剂.
- 识别聚合体配方临床翻译的障碍.
主要方法:
- 审查已建立的聚合物制技术,包括直接水化,薄膜水化,电穿孔,pH开关,溶剂转移,乳液方法,闪光纳米沉和微流体合成.
- 基于结构和功能的聚合体的分类:光学,向性联体装饰,刺激反应和多孔的聚合体.
- 分析聚合体作为药物输送载体,以改善治疗结果.
主要成果:
- 聚合体具有可调节的特性,可用于控制药物封装和释放.
- 不同的制备方法产生了具有独特性质的聚合体,影响药物的保存.
- 聚合体在提高化疗药物,免疫治疗药物和生物制剂的输送方面表现有前途.
- 有针对性的输送和对刺激有反应的设计提高了治疗效率和安全性.
结论:
- 聚合体代表了先进药物输送的有希望的平台,提高了稳定性,疗效和有针对性的作用.
- 它们的应用可以显著增强癌症等疾病的治疗方法,并改善敏感生物制剂的输送.
- 清晰的监管框架对于将聚合体配方推向临床试验和市场至关重要.
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