非常大的孔隙介质生物活性酸盐玻璃:在药物加载/释放和生物活性方面,对经典介质生物活性玻璃的行为比较
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Updated: Jul 5, 2025
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Preparation of Functional Silica Using a Bioinspired Method
Published on: August 1, 2018
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Debora Carrozza1, Erika Ferrari1, Gianluca Malavasi1
1Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy.
Materials (Basel, Switzerland)
|January 23, 2024
概括
带有和离子的大孔半孔 (LPMS) 显示了用于骨再生的药物加载和释放的增强. 这些材料与经典的半孔二氧化相比,具有优越的生物活性特性.
科学领域:
- 生物材料科学 生物材料科学
- 材料化学 材料化学
- 纳米技术纳米技术
背景情况:
- 骨质疏松症和骨缺陷需要先进的骨组织再生策略.
- 将Ca2+和Ga3+等生物活性离子纳入结构可以增强治疗效果.
- 大孔半孔 (LPMS) 具有改善药物递送和生物活性的潜力.
研究的目的:
- 合成和描述含有Ca2+和Ga3+的LPMS用于骨再生.
- 用LPMS和经典的半孔 (MS) 来评估尼的加载和释放动力学.
- 评估合成材料的生物活性和离子释放特征.
主要方法:
- 索尔凝蒸发诱导自组合 (EISA) 工艺用于合成LPMS和MS.
- 吸附/脱附和Hg-孔径测量用于孔隙结构的表征.
- 尼辛负荷/释放试验,扫描电子显微镜 (SEM),感应合等离子光学发射光谱 (ICP-OES),里埃变换红外光谱 (FT-IR),SEM能量分散光谱 (EDS) 和X射线粉末衍射 (XRDP) 用于材料分析.
主要成果:
- 在LPMS中,孔径在20-60nm和200-600nm之间.
- 与传统成员国相比,LPMS的装载和释放能力翻了一番.
- 从LPMS在模拟体液 (SBF) 中观察到高释放的Ca2+和Ga3+离子.
- SEM,FT-IR,EDS和XRDP证实了含有Ca的LPMS的结构完整性和生物活性行为.
结论:
- 带有Ca2+和Ga3+的LPMS显示了治疗剂的增强载荷和释放能力.
- 在用于骨再生的药物输送应用中,LPMS表现优于经典MS.
- 合成的LPMS具有固有的生物活性特性,使其成为骨组织工程的前景.
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