干细胞移植后女性的性功能障碍以及对夫妻关系的影响
Mihaela Plotogea1,2, Anca Zgura2, Claudia Mehedințu2,3
1Department of Obstetrics and Gynecology, "Nicolae Malaxa" Clinical Hospital, 022441 Bucharest, Romania.
Life (Basel, Switzerland)
|January 23, 2024
概括
血造干细胞移植 (HSCT) 幸存者经常经历性功能障碍和阴道缩,对人际关系产生负面影响. 这些长期影响需要医疗照顾,与其他移植后疾病相比.
科学领域:
- 在瘤学瘤学.
- 妇科 妇科 妇科 妇科
- 生殖医学 生殖医学
背景情况:
- 造血干细胞移植 (HSCT) 改善了血液恶性瘤的存活率.
- 在HSCT中的调节方案可能会导致严重的尿生殖系统损伤,导致过早的卵巢衰竭,阴道缩和性功能障碍.
- 这些后果往往会损害HSCT幸存者的长期生活质量.
研究的目的:
- 评估HSCT后女性性功能障碍的患病率和严重程度.
- 通过使用女性性功能指数 (FSFI) 评估与HSCT相关的妇科损伤对性功能的影响.
- 为了确定性功能障碍对HSCT幸存者的夫妻关系的影响.
主要方法:
- 一项前性观察性比较研究,涉及38名女性后异构HSCT和38名健康对照.
- 用临床检查和FSFI进行主观和客观评估.
- 随访评估是在移植后的基线,一年和三年进行的.
主要成果:
- 在HSCT组中,根据FSFI得分,观察到 vulvovaginal 缩 (76.32%) 和性功能障碍 (92.10%) 的高发病率.
- 尽管出现了一些改善,但轻微的膜缩症在3年内持续在81.58%和异常的FSFI得分在21.05%.
- 与对照组相比,HSCT幸存者表现出明显较差的性功能和FSFI得分,对夫妇关系产生了统计学上显著的负面影响.
结论:
- 接受HSCT的女性经常经历持续的解剖,功能和心理性健康问题.
- 性功能障碍严重损害了HSCT幸存者的生活质量和婚姻关系.
- 对长期的HSCT幸存者来说,对性健康的全面评估和管理至关重要.
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