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Updated: Jul 5, 2025

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
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轻链 Amyloidosis:伟大的骗子

Georgia Stefani1, Evangelia Kouvata1, George Vassilopoulos1,2

  • 1Department of Hematology, Larisa University Hospital, 41110 Larisa, Greece.

Life (Basel, Switzerland)
|January 23, 2024
PubMed
概括

轻链氨基粉症 (AL) 是一种罕见的血细胞疾病,导致器官损伤. 本综述解决了医生对AL氨基粉症诊断和治疗的疑问.

关键词:
氨基粉症是什么?诊断程序 诊断程序 诊断程序免疫球体蛋白轻链免疫球体素治疗干预治疗干预

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Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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