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血液计数衍生的炎症标志物对牛皮病进展的影响

Oana Mirela Tiucă^1,2,3, Silviu Horia Morariu^2,3, Claudia Raluca Mariean^1,4

¹Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania.

Life (Basel, Switzerland)

|January 23, 2024

概括

低成本的血液标记物,如中性粒细胞与淋巴细胞比率 (NLR),可以预测牛皮的严重程度. 导出的中性粒细胞与淋巴细胞比率 (d-NLR) 是所有牛皮严重程度的关键指标.

科学领域:

免疫学免疫学免疫学
皮肤病学皮肤病学
血液学血液学血液学

背景情况:

牛皮是一种慢性,免疫介导的疾病,与全身炎症和并发症有关.
目前的监测方法,如细胞因子水平昂贵且难以获得.
需要负担得起和可靠的生物标志物来评估疾病的进展和结果.

研究的目的:

为了评估血液计数衍生的炎症标志物在预测牛皮的疗效.
为了确定与牛皮严重程度相关的预后因素.
为了确定这些标记物对疾病监测的可靠性.

主要方法:

根据身体表面积 (BSA) 评分,患者被分为轻度,中度和严重的牛皮群.
分析了血细胞计数,包括白细胞计数 (WBC),中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR),衍生中性粒细胞与淋巴细胞比率 (d-NLR),全身免疫指数 (SII),全身炎症反应指数 (SIRI) 和全身炎症总指数 (AISI).
进行了统计分析,以将这些标志物与疾病严重程度相关联,并确定独立的预后因素.

主要成果:

一些标志物,包括WBC,NLR,PLR,d-NLR,SII,SIRI和AISI,与牛皮的严重程度有正相关性 (p < 0.005).
NLR,SII和d-NLR被确定为轻度和中度牛皮的独立预后因素 (p <0.05).
在所有严重程度组中,d-NLR成为唯一独立的预后因素,其值在1.49至2.19之间,表明中度牛皮.

结论:

血液计数衍生的炎症标志物,特别是d-NLR,NLR和SII,是评估系统性炎症和预测牛皮疾病严重程度的有价值和具有成本效益的工具.
d-NLR是一种可靠的预后因素,适用于所有牛皮严重程度.
这些发现支持使用常规血液计数来监测牛皮的进展和指导治疗决策.

关键词:

血液标记物血液标记物疾病的严重程度.这是一种炎症炎症炎症炎症.炎症性皮肤疾病炎症性皮肤疾病牛皮是一种牛皮.

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