没有缺陷会影响半球间和半球内血流的适应,对单侧 Carotid 动脉封闭
László Hricisák1,2, Éva Pál1,2, Dorina Nagy1,2
1Institute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary.
International journal of molecular sciences
|January 23, 2024
概括
降低氧化 (NO) 的可用性会影响大脑血流 (CBF) 调节,导致动脉堵塞 (CAO). 这种NO缺乏会阻碍大脑的运作.
科学领域:
- 神经科学是一个神经科学.
- 脑血管生理学 脑血管生理学
- 血管生物学 血管生物学
背景情况:
- 动脉狭窄 (CAS) 是血管认知障碍 (VCI) 的一个主要危险因素.
- 大脑血流 (CBF) 的调节对大脑功能至关重要,特别是在大脑动脉堵塞 (CAO) 后.
- 氧化 (NO) 在维持脑血管平衡中起着关键作用.
研究的目的:
- 为了调查氧化 (NO) 生产受损的作用,损害大脑血流 (CBF) 恒温在单方面动脉阻塞 (CAO) 后.
- 为了测试降低NO可用性的假设,损害了大脑对降低动脉血流的适应性反应.
主要方法:
- 使用了三种NO合成受损的小鼠模型:NOS1淘汰,NOS1/3双淘汰和L-NAME治疗的小鼠.
- 使用激光光斑对比成像 (LSCI) 评估单侧动脉阻塞 (CAO) 后区域CBF变化.
- 检查了合资担保船的结构变化.
主要成果:
- 患有NO生产受损的小鼠表现出受损的CBF适应CAO.
- 在NO合成酶异型体的遗传缺陷导致了状附带血管的形性增加.
- 降低了NO的生物可用性,降低了CAO后的半球间和半球内血流再分配.
结论:
- 氧化 (NO) 的产生对于大脑皮层微循环对单侧动脉阻塞 (CAO) 的适应性反应至关重要.
- 降低NO的生物可用性有助于破坏CBF的平衡,并可能加剧VCI风险.
- 向NO通路可能为管理CAS相关认知衰退提供治疗策略.
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