激素,向和组合疗法治疗乳腺癌:从人类到狗
Chiao-Hsu Ke1,2, Chao-Nan Lin1,2,3, Chen-Si Lin4
1Sustainable Swine Research Center, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
International journal of molecular sciences
|January 23, 2024
概括
人类和狗的乳腺瘤有相似之处. 对犬乳腺瘤 (CMT) 激素和向治疗的研究是有限的,这凸显了对新型治疗和在狗身上进行临床试验的需要,以使人类和动物的健康受益.
科学领域:
- 比较性瘤学研究
- 兽医医学 兽医医学 兽医医学
- 人类瘤学 人类瘤学
背景情况:
- 乳腺癌 (BC) 是女性最常见的癌症,而犬乳腺瘤 (CMTs) 是雌性狗的主要瘤.
- 人类乳腺癌 (HBC) 和CMT表现出类似的瘤行为,使比较瘤学成为一个有价值的领域.
- 目前对激素受体表达BCs的治疗包括激素治疗和对Her2的单克隆抗体,但药物耐药性仍然是一个重大挑战.
结论:
- 迫切需要更新的激素/向疗法和CMT的新型免疫疗法.
- 未来的研究应该专注于为患有CMT的狗制定精确的治疗策略.
- 在狗身上进行精心设计的临床试验有望为人类和狗乳腺癌的治疗方法提供进展.
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