花茎中的生物可访问的有机硫化合物调节了参与炎症性肠病的炎症媒介
Antonio Costa-Pérez1, Paola Sánchez-Bravo1,2, Sonia Medina1
1Laboratorio de Fitoquímica y Alimentos Saludables (LabFAS), CEBAS-CSIC, Espinardo, 30100 Murcia, Spain.
International journal of molecular sciences
|January 23, 2024
概括
花茎提取物,优化为硫黄 (SFN),显示显著的抗炎作用,没有细胞毒性. 这项研究强调了SFN作为肠道炎症的潜在自然治疗方法.
科学领域:
- 营养科学 营养科学
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 炎症性疾病对全球的发病率和死亡率做出了重大贡献.
- 植物衍生生物活性化合物为传统抗炎药物提供了更少副作用的替代品.
- 硫福拉 (SFN) 是西兰花中发现的关键生物活性化合物,具有潜在的抗炎性质.
研究的目的:
- 为了研究加工的西兰花茎的生物可访问部分的抗炎活性.
- 为了确定最大限度地提高硫甲 (SFN) 度的最佳加工条件.
- 评估西兰花衍生的SFN在减少肠道炎症方面的安全性和有效性.
主要方法:
- 从西兰花茎材料中提取和定量葡萄糖酸盐 (GSL) 和SFN.
- 在不同的加工条件下评估SFN生物可访问性.
- 提取物在Caco-2细胞上的细胞毒性测试.
- 测量对提取物反应的促炎性细胞因子 (IL-6,IL-8,TNF-α) 的产生.
主要成果:
- 经过加工的西兰花茎产生了不同的GLS含量,SFN是主要的稳定,生物可访问的化合物.
- 高同硫酸盐 (ITC) 材料提供了最高度的可生物利用的SFN (~4.00 mg/kg dw).
- 提取物通过减少促炎性细胞因子而表现出显著的抗炎活性,而不会对Caco-2细胞表现出细胞毒性.
结论:
- 菜茎的优化加工可以提高SFN的生物可访问度.
- 从西兰花茎中提取的SFN显示出作为治疗肠道炎症的治疗剂的前景.
- 这些发现支持SFN作为治疗炎症疾病的自然,安全替代品的潜力.
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