基于蛋白质和的药物的当前和有前途的口服输送方法
Michał Nicze1, Maciej Borówka1, Adrianna Dec1
1Department of Internal Medicine and Clinical Pharmacology, Faculty of Medical Sciences, Medical University of Silesia in Katowice, Medyków 18, 40-752 Katowice, Poland.
International journal of molecular sciences
|January 23, 2024
概括
科学家正在开发新的和蛋白质药物 (PPD) 口服输送方法,以克服胃肠道不稳定性和吸收不良等挑战,改善患者的服药性.
科学领域:
- 制药科学 制药科学
- 生物技术是生物技术.
- 药物输送系统 药物输送系统
背景情况:
- 和蛋白质药物 (PPs) 在医学上有着悠久的历史,糖尿病胰岛素就是一个很好的例子.
- 由于口服生物可用性较差和胃肠道 (GI) 系统不稳定,对PPs的表肠道注射是常见的.
- 口服药物供应是患者遵守的首选,但PP面临诸如酶降解和有限的透性等挑战.
研究的目的:
- 审查用于口服和蛋白质药物 (PPD) 的新策略.
- 突出现有和新兴的口腔PPD治疗方法.
- 为了解决PPs的腹腔内服的局限性.
主要方法:
- 对PP的先进药物输送系统的科学文献的审查.
- 讨论肠道管理的各种配方和技术方法.
- 分析治疗应用和口服 PPs 的市场可用性.
主要成果:
- 目前正在探索许多用于口服PPD的创新方法,包括纳米粒子,水凝和微针.
- 这些策略旨在增强PPD的稳定性和透性,跨越地图学障碍.
- 已经开发了几种口服PPD治疗方法,目前正在使用.
结论:
- 克服口服吸收挑战对于推进和蛋白质药物治疗至关重要.
- 新型的输送系统为亲肠道途径提供了有前途的替代方案,可能改善患者的治疗结果.
- 继续在这一领域的研究对于扩大PP的治疗潜力至关重要.
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