患有代谢综合征的患者循环生物标志物和身体成分参数之间的关系:一个基于社区的研究
Nader Tarabeih1, Alexander Kalinkovich2, Shai Ashkenazi1
1Department of Morphological Sciences, Adelson School of Medicine, Ariel University, Ariel 40700, Israel.
International journal of molecular sciences
|January 23, 2024
概括
这项研究确定了主要的肥胖和炎症标志物,如脂肪质量和单细胞与高密度胆固醇的比率,作为代谢综合征 (MetS) 的重要预测因素. 研究结果揭示了MetS和肥胖因素之间的复杂,与年龄相关的联系.
科学领域:
- 生物医学研究的研究.
- 代谢性疾病研究研究.
- 肥胖和炎症研究的研究.
背景情况:
- 代谢综合征 (MetS) 涉及复杂的生理和代谢异常.
- 识别可靠的生物标志物对于理解MetS病原体和开发干预措施至关重要.
- 肥胖和炎症被认为是导致MetS发展的关键因素.
研究的目的:
- 确定循环因素和身体组成参数作为MetS的潜在生物标志物.
- 研究肥胖相关因素,炎症标志物和MetS之间的关系.
- 探索年龄和性别对MetS和相关因素的影响.
主要方法:
- 基于人口的研究,对来自种族同质群体的1079个人 (18-80岁) 进行了研究.
- 使用ELISA测量血溶性标记物,通过生物阻抗分析 (BIA) 测量身体成分.
- 统计分析包括混合效应回归和附加贝叶斯网络建模.
主要成果:
- 脂肪质量/体重比 (FM/WT),瘦素/子素 (L/A) 比率,GDF-15和单细胞与高脂胆固醇比率 (MHR) 是MetS的显著预测因素.
- 年龄,性别,MHR和FM/WT与MetS表现有直接关联.
- 贝叶斯网络分析表明,MetS可能会影响GDF-15和L/A比率水平.
结论:
- 脂肪组织表型和炎症标志物与MetS密切相关.
- 在MetS和肥胖相关因素之间存在复杂的,年龄相关的关系.
- 对MetS的多因素性质和潜在的生物标志物实用性的新见解.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
93
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
93
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
159
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
159
01:29Cholesterol: Significance and Regulation
549
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
549
01:24Obesity
505
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
505