在急性缺血性中风中进行血栓切除术期间的神经保护:对未来治疗方法的审查
Vikalpa Dammavalam1, Sandra Lin2, Sayedatun Nessa1
1Department of Neurology, Stony Brook University Hospital, Stony Brook, NY 11794, USA.
International journal of molecular sciences
|January 23, 2024
概括
血管内血栓切除术可以改善中风的存活率,但并不总是改善功能. 针对氧化应激和缺血-反损伤的新型神经保护疗法显示出更好的中风恢复结果的希望.
科学领域:
- 神经学 神经学
- 血管医学 血管医学
- 神经保护是一种神经保护.
背景情况:
- 在全球范围内,中风仍然是导致死亡和残疾的主要原因.
- 血管内血栓切除术显著降低了死亡率,但往往产生不理想的功能结果.
- 在重新道化率和症状改善之间存在差距,这表明需要辅助疗法.
研究的目的:
- 审查神经保护剂和辅助疗法的进展,用于内血管结血切除术后的护理.
- 探索向缺血 - 反损伤和氧化应激在中风恢复中的作用.
- 突出内血管治疗和神经保护的综合方法的潜力.
主要方法:
- 对各种神经保护剂的临床前和临床证据的审查.
- 针对氧化应激的治疗方法及其下游效应因子的分析.
- 检查镇静和血压管理在中风结果中的作用.
主要成果:
- 临床前研究表明,神经保护剂通过预防氧化应激会产生积极的效果.
- 包括尿酸,埃达拉和核因子红色素2相关因子2 (Nrf2) 在内的多种药物显示出有前途.
- 镇静和血压管理是血栓切除术后护理的关键组成部分.
结论:
- 辅助神经保护疗法对于改善内血管血栓切除术后的功能结果至关重要.
- 向缺血-再输液损伤和氧化应激提供了一种有前途的中风恢复策略.
- 结合内血管治疗和神经保护的协同方法可以优化中风护理并减少残疾.
相关概念视频
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...