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Updated: Jul 5, 2025

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level
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SMC5/6 通过对COP9信号的负调节促进复制叉稳定性

Michelle J Xu1, Philip W Jordan1,2

  • 1Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.

International journal of molecular sciences
|January 23, 2024
PubMed
概括

在小鼠细胞中,SMC5/6复合体对于重新启动停滞不前的DNA复制分叉至关重要. 失去SMC5/6会导致叉子不稳定,因为它会影响叉子保护因子和MRE11活动.

关键词:
造成的DNA损伤是DNA损伤.修复DNA的修复DNA的修复复制DNA复制DNA复制DNA复制在SMC5/6中使用.胚胎干细胞是一种胚胎干细胞.染色体的结构维护是染色体的结构维护.

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