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多功能纳米平台的POSS工程用于化学-温和光热协同疗法

Zhengye Gu¹, Xiaochuan Geng², Shanyi Guang³

¹State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science, Engineering & Research Center for Analysis and Measurement, Donghua University, Shanghai 201620, China.

International journal of molecular sciences

|January 23, 2024

概括

这项研究引入了一种新的纳米平台,将化疗和轻度光热疗法结合起来,用于增强瘤治疗. 基于基的多面寡合体系统 (POSS-SQ-DOX) 显示出显著的协同效应和低毒性.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

化疗-轻度光热协同疗法通过将化疗与轻度高温症结合起来,为癌症治疗提供了一种有前途的方法.
开发有效的纳米载体对于提供治疗剂和提高治疗疗效,同时最大限度地减少副作用至关重要.

研究的目的:

开发一个多功能纳米平台 (POSS-SQ-DOX),整合化疗和轻度光热疗法,用于协同治疗癌症.
评估光热特性,协同治疗效果和开发的纳米平台的生物相容性.

主要方法:

合成了一种基于多面体的寡合性塞斯基西洛 (POSS) 的纳米平台,将SQ-N作为光热剂和多克索鲁比 (DOX) 作为化疗药物.
加入聚乙烯甘醇 (PEG) 来增强细胞透性并防止SQ-N聚合.
评估光热转换效率,体外和体外治疗疗效和细胞毒性.

主要成果:

POSS-SQ-DOX NP显示了高光热转换效率 (62.3%) 和稳定性.
0.72的组合指数 (CI) 证实了化疗和光热疗法之间的协同效应.
POSS-SQ-DOX NP实现了显著的细胞死亡率 (74.7%) 和瘤抑制率 (72.7%),表现优于单剂疗法.
在体外和体外毒性测试显示出出色的生物相容性和细胞毒性缺失.

结论:

开发的POSS-SQ-DOX纳米平台有效地结合化疗和轻度光热疗法,表现出显著的协同抗癌效应.
纳米平台的稳定性,高光热效率,增强的细胞透性和优异的生物相容性突出显示了其在化疗-轻度光热治疗中的临床应用潜力.

关键词:

基于POSS的纳米平台化疗-温和的光热疗法高抑制率的高抑制率.在Squaraine中,我们可以使用Squaraine.有协同效应的效应.

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