绿色合成的聚合物约多福与西红花作为抗菌剂
Zehra Edis1,2, Samir Haj Bloukh2,3, Hamed Abu Sara2,3
1Department of Pharmaceutical Sciences, College of Pharmacy and Health Science, Ajman University, Ajman P.O. Box 346, United Arab Emirates.
International journal of molecular sciences
|January 23, 2024
概括
一种新型的抗菌药物配方,将聚烯罗立复合物与西兰花和花结合起来,显示出对抗性病原体的强大活性. 这种天然抗菌剂有效地对抗医疗用品上的感染,并在长期储存后显示出更强的疗效.
科学领域:
- 材料科学 材料科学 材料科学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗菌素耐药性 (AMR) 构成了全球健康的重大威胁,使得传统的抗生素越来越无效.
- 迫切需要新的抗菌药物战略,特别是针对弱势群体.
- 天然产品,如药用植物提取物和,作为传统抗生素的替代品或辅助剂显示出希望.
研究的目的:
- 为了合成和表征一种新的抗菌生物配方 (AV-PVP-Thyme-I2),使用聚烯 (PVP) 复合, * 乳腺素 (Thymus Vulgaris) * (乳腺素) 和 * (Aloe Barbadensis) *米勒 (AV).
- 评估这种配方的疗效与10个参考病原体的小组对比.
- 在应用于各种医疗材料时评估配方的抗菌活性.
主要方法:
- 使用一合成方法创建了AV-PVP-Thyme-I2配方.
- 使用SEM/EDS,UV-vis,拉曼,FTIR和XRD分析进行了配方的表征.
- 通过对无菌磁盘,手术,棉花带,手术口罩和KN95口罩的磁盘扩散方法来评估抗菌活性,并与 gentamycin 和 nystatin 进行比较.
主要成果:
- 合成的AV-PVP-Thyme-I2配方已成功准备和表征,证实了其纯度,成分和形态.
- 该生物配方对大多数测试的参考病原体表现出显著的广泛抗菌活性,并表现出强大的抗真菌和抗菌特性.
- 当该配方应用于棉带和面膜时,观察到出色的抗菌性能. 值得注意的是,抗微生物药物的有效性在储存18个月后增加.
结论:
- 该AV-PVP-Thyme-I2配方代表了一种强大的天然抗菌剂,具有对抗耐药微生物感染的巨大潜力.
- 该配方有效防止各种医疗材料上的微生物扩散,建议在伤口护理和感染控制中应用.
- 长时间储存后增强的抗微生物活性表明该配方的稳定性和长期可行性.
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