复制人体皮肤在体外:应该考虑微生物群吗?
Andrea Galvan1, Carlo Pellicciari2, Laura Calderan1
1Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.
International journal of molecular sciences
|January 23, 2024
概括
人体皮肤模型对于研究皮肤屏障功能和药物效应至关重要. 将皮肤微生物群纳入这些模型可以提高它们在模拟体内条件的准确性.
科学领域:
- 皮肤病学 皮肤病学
- 微生物学 微生物学
- 生物技术是生物技术.
背景情况:
- 皮肤提供关键功能,包括保护,热调节,感觉和药物输送.
- 它拥有物理,化学和免疫屏障,由皮肤微生物群增强.
- 需要体外模型来研究动态皮肤过程,克服生物样本的局限性.
研究的目的:
- 审查和讨论当前体外人类皮肤模型的优缺点.
- 突出将皮肤微生物群纳入这些模型的好处.
- 提高皮肤研究的体内相关性.
主要方法:
- 对现有的体外人类皮肤模型的文献综述.
- 对模型复杂性的分析 (化学,结构,细胞).
- 评估微生物群纳入的影响.
主要成果:
- 存在各种不同复杂度的体外人体皮肤模型.
- 目前的模型在完全复制体内条件时面临挑战.
- 微生物群的包含为模型忠实性提供了显著的优势.
结论:
- 在体外人体皮肤模型是研究的宝贵工具.
- 整合皮肤微生物群对于提高模型准确性至关重要.
- 未来的模型应该优先考虑微生物群的纳入,以获得更好的体内仿真.
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