与亚托匹性皮肤炎相关的胃肠道并发症-一篇叙述性评论
Weronika Zysk1, Alicja Mesjasz2, Magdalena Trzeciak1
1Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland.
International journal of molecular sciences
|January 23, 2024
概括
亚托邦性皮肤炎 (AD) 与胃肠道问题比以前认为的更多. 需要进行进一步的研究,以了解AD与食物过敏和炎症性肠病等疾病的共同发生增加背后的原因.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 亚托皮炎 (AD) 越来越多地被认为是一种超出皮肤表现的全身性疾病.
- 流行病学研究表明,阿尔茨海默病患者中各种疾病的患病率较高.
- 胃肠道 (GI) 疾病是经常观察到的伴随性疾病在患有亚托邦性皮肤炎的个体.
研究的目的:
- 审查阿托皮性皮肤炎患者的胃肠道并发病的流行病学.
- 探索潜在的机制,为AD和胃肠道疾病的同时发生.
- 突出需要进一步调查AD和GI条件之间的关系.
主要方法:
- 在PubMed数据库中进行全面的文献搜索.
- 对有关阿托皮性皮肤炎和胃肠道疾病同时发生的流行病学数据的分析.
- 对观察到的关联的潜在病因因素的讨论.
主要成果:
- 多种胃肠道疾病,包括食物敏感性,食物过敏,性食道炎,FPIES,克罗恩病,性结肠炎,腹病,IBS和GERD,在患有AD的患者中更为常见.
- 这些疾病的患病率在患有亚托邦性皮肤炎的人群中显著增加.
- 驱动这种增加的同时发生的潜在机制在很大程度上仍然不清楚.
结论:
- 亚托邦性皮肤炎与更高的胃肠道并发症负担有关.
- 阿尔茨海默病和胃肠道疾病之间的关系是复杂的和多因素的.
- 进一步的研究是必不可少的,以阐明机制,并告知临床管理.
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