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COVID-19对脏移植功能的影响一年后开始

Agnieszka Malinowska¹, Jakub Ruszkowski¹, Marta Muchlado¹

¹Department of Nephrology Transplantology and Internal Medicine, Medical University of Gdansk, 80-952 Gdansk, Poland.

Medicina (Kaunas, Lithuania)

|January 23, 2024

概括

COVID-19的严重程度影响了移植接受者.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
传染性疾病传染性疾病
移植免疫学移植免疫学

背景情况:

移植接受者 (KTRs) 面临严重COVID-19的风险增加.
SARS-CoV-2 感染对移植功能的长期影响需要进一步调查.

研究的目的:

评估COVID-19临床过程对KTRs移植功能的长期影响.
确定影响COVID-19后移植功能下降的因素.

主要方法:

对128个已确认感染SARS-CoV-2的KTR进行了回顾性分析.
根据氧气治疗的需要,将COVID-19分为轻度和重度的分类.
估计膜过率 (eGFR) 在感染后一年的变化评估,考虑性别,年龄,吸烟,糖尿病 (DM) 和心血管疾病 (CVD).

主要成果:

在KTR中,严重的COVID-19与老年,吸烟,DM和CVD有关.
在康复一年后,在患有严重COVID-19的男性KTR中观察到显著的eGFR下降.
根据COVID-19的严重程度,在女性KTR中没有发现对eGFR下降的显著影响.

结论:

COVID-19感染可能导致KTRs的移植功能恶化.
疾病严重程度和男性性别与COVID-19后eGFR的较大下降有关.
针对性监测和预防策略对于KTR,特别是男性来说至关重要.

关键词:

在 COVID-19 疫情中,接种器的功能移植脏的接受者接受者

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