超越急性阶段:COVID-19对功能能力和原血栓风险的长期影响-A试点研究
Doina-Clementina Cojocaru1,2, Florin Mitu1,2,3,4, Maria-Magdalena Leon1,2
1Department of Medical Specialties I and III, "Grigore T. Popa" University of Medicine and Pharmacy, University Street No. 16, 700115 Iasi, Romania.
Medicina (Kaunas, Lithuania)
|January 23, 2024
概括
肺纤维化长期COVID患者在感染后两年表现出持续的炎症和凝血风险. 升高的D-二聚物水平预测肺功能减弱 (DLCO),表明尽管整体功能恢复,但潜在的预后价值.
科学领域:
- 肺部病理学 肺部病理学
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
背景情况:
- 评估COVID-19的长期后果对于了解慢性疾病进展至关重要.
- 调查COVID-19感染后的原血栓和炎症状态可以确定潜在的治疗点.
研究的目的:
- 在急性感染后至少两年,评估COVID-19幸存者的慢性前炎症,前血栓和功能状态.
- 确定在COVID-19后患者,特别是肺纤维化患者中具有潜在治疗和预后价值的特定参数.
主要方法:
- 对117名COVID-19患者的回顾性描述性研究,感染后至少两年重新评估.
- 队列被分为有肺纤维化和没有肺纤维化 (通过高分辨率计算机断层扫描诊断) 的组.
- 分析炎症标志物 (CRP,WBC,中性粒细胞,费里丁),前血栓标志物 (D-二次数,MPV),心脏参数 (心率,QT间隔) 和肺功能测试 (呼吸计,DLCO,6分钟步行测试).
主要成果:
- 肺纤维化患者的C-反应蛋白,白细胞数,中性粒细胞,平均血小板体积,乳酸脱酶和D-二次体显著增加.
- 升高的D-二聚物水平与血红蛋白校正的扩散能力 (DLCO) 有着强烈的负相关性.
- ROC分析表明,持续高的D-二次元水平预测了低DLCO值 (AUC=0.772,p<0.001).
结论:
- 与COVID-19相关的肺纤维化与持续的长期炎症和前血栓状况有关,即使功能恢复.
- 在COVID-19后的患者中,D-二聚物水平升高可能是DLCO受损的预测因素.
- 这些发现凸显了对COVID-19幸存者的慢性心血管和肺风险的持续监测和潜在干预的需要.
相关概念视频
Anticoagulant Drugs: Low-Molecular-Weight Heparins
701
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
701
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Psychoneuroimmunology: Cardiovascular Disease
31
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
31
Stress Prevention and Stress Management Techniques IV
29
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...
29
COPD: Pathogenesis and Clinical Features
275
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
275
Factors Affecting Illness
4.2K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.2K


