前列腺癌的雄激素缺乏治疗:专注于认知功能和情绪
Allison B Reiss1, Shelly Gulkarov1, Aaron Pinkhasov2
1Department of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA.
Medicina (Kaunas, Lithuania)
|January 23, 2024
概括
前列腺癌的雄激素剥夺疗法 (ADT) 可能会影响认知功能和情绪. 在ADT患者和阿尔茨海默病患者之间共享的基因表明了需要进一步调查的潜在联系.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 内分泌学 在内分泌学.
背景情况:
- 前列腺癌是男性癌症死亡的主要原因.
- 抗雄激素剥夺疗法 (ADT) 是转移性前列腺癌的主要治疗方法.
- ADT涉及抗雄激素药物,可能会影响认知功能,情绪和生活质量.
研究的目的:
- 审查ADT对认知功能,情绪和生活质量的影响.
- 分析ADT和阿尔茨海默病之间的关系.
- 探索ADT和阿尔茨海默病之间的共同遗传机制.
主要方法:
- 审查关于ADT及其影响的现有文献.
- 在ADT和阿尔茨海默病患者的前列腺癌患者中对基因表达的比较分析.
- 描述神经认知测试用于评估前列腺癌患者的认知能力.
主要成果:
- ADT可能导致白质完整性降低,并影响下丘脑功能.
- 在ADT的前列腺癌患者和阿尔茨海默病患者之间发现了30多个共享基因.
- ADT与对认知,情绪和生活质量的潜在不良影响有关.
结论:
- ADT可能会产生显著的生理影响,影响认知功能和情绪.
- 共同的遗传因素表明ADT和阿尔茨海默病之间存在潜在的机械联系.
- 需要进一步的研究来了解荷尔蒙变化,认知缺陷和情绪障碍之间的关系.
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