坚持氧尿素和患者对状细胞疾病和氧尿素的看法:一个横截面研究
Mohammed Ali Madkhali1, Faisal Abusageah2, Faisal Hakami2
1Department of Internal Medicine, Division of Hematology and Oncology, Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia.
Medicina (Kaunas, Lithuania)
|January 23, 2024
概括
在沙特阿拉伯的状细胞病 (SCD) 患者中,基尿素 (HU) 粘附性较低,超过81%的人报告粘附性差. 针对性教育对于改善人力资源使用和有效管理SCD至关重要.
科学领域:
- 血液学 血液学 血液学
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 氧尿素 (HU) 是状细胞疾病 (SCD) 的基石疗法.
- 在SCD管理中,患者对HU的不理想坚持仍然是一个重大挑战.
- 了解患者对SCD和HU的看法对于提高治疗坚持至关重要.
研究的目的:
- 为了评估沙特阿拉伯贾赞地区SCD患者的基尿素坚持.
- 评估患者对SCD的看法以及他们对HU治疗的理解.
- 在这个人群中识别与酸粘附相关的因素.
主要方法:
- 一项涉及217名SCD患者的横截面研究.
- 数据通过自我管理问卷收集,包括人口统计,SCD影响,简短的疾病感知问卷 (B-IPQ) 和莫里斯基药物坚持量表 (MMAS-8).
- 统计分析包括描述性统计,t测试和千平方测试 (p<0.05显著性).
主要成果:
- 57.6%的SCD患者正在使用HU,其中81.6%的用户报告了较低的坚持.
- 在感染患者和接受重复输血的患者中观察到较低的坚持.
- 男性患者和那些患有严重疾病并发症 (ICU入院,经常住院) 的患者报告说,他们对SCD后果和担忧的看法更高.
结论:
- 尽管HU的疗效很高,但其在SCD患者中的不足使用是令人担忧的.
- 医疗保健提供者应该教育患者关于HU的好处和副作用管理,以改善遵守.
- 建议针对感染或经常住院的患者进行量身定制的教育干预.
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