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在接受预定皮肤冠状动脉干预的患者中,兰洛,缺血性预调和心脏保护之间存在关联

Konstantinos Kourtis¹, Angeliki Bourazana², Andrew Xanthopoulos²

¹Department of Cardiology, Konstantopouleio General Hospital, 14233 Athens, Greece.

Medicina (Kaunas, Lithuania)

|January 23, 2024

概括

结合远程缺血预调 (RIPC) 与罗纳素预治疗,可以减少皮肤冠状动脉干预 (PCI) 期间心肌损伤. 这种方法显示了心脏酶水平的降低,这表明在接受PCI的患者中缺血诱导减少.

科学领域:

心脏病学心脏病学
心血管研究研究心血管研究
药理学药理学是指药理学的学科.

背景情况:

远程缺血预调 (RIPC) 在穿皮冠状动脉再血管化过程中保护心肌缺血-再输液损伤.
兰诺是一种用于慢性心痛的抗缺血药物,但其与PCI患者的RIPC的联合作用尚未研究.

研究的目的:

在接受皮肤冠状动脉干预 (PCI) 的患者中研究 ranolazine 前期治疗和 RIPC 的联合作用.

主要方法:

一项前性研究招募了150名接受非突发性皮肤冠状动脉再血管化的患者.
患者被分为三个组:对照组,仅RIPC组和RIPC组与 ranolazine 预治疗组.
在手术后监测血清酶水平 (热素I,CPK,CK-MB).

主要成果:

与对照组相比,Ranolazine组在24小时内表现出与对照组相比,Troponin I水平的增加明显较低.
与预先条件化组相比,Ranolazine组观察到显著较低的CPK水平在4,10和24小时.
与对照组相比,罗纳拉组在10小时内也显示出明显较低的CK-MB水平.

结论:

将RIPC与罗纳素预治疗结合起来,可能会减少在预定冠状动脉手术期间的缺血诱导.
结合治疗组中心肌酶水平较低表明对缺血-再输血损伤有保护作用.

关键词:

心脏保护心脏保护冠状动脉是一个冠状动脉.干预干预干预干预干预干预通过皮肤通过皮肤.这是一个预先条件.对于 ranolazine 的使用情况.

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