在COVID和非COVIDARDS中的易受定位和分子生物标志物:叙述性审查
Savino Spadaro1,2, Jose Daniel Jimenez-Santana3, Riccardo La Rosa1,2
1Department of Translational Medicine, University of Ferrara, 44124 Ferrara, Italy.
Journal of clinical medicine
|January 23, 2024
概括
俯卧 (PP) 改善了急性呼吸困扰综合征 (ARDS) 的结果. 本综述研究了生物标志物在PP期间的行为及其在ARDS中预测患者结果的潜力.
科学领域:
- 关键护理医学 关键护理医学
- 肺部病理学 肺部病理学
- 生物标志物研究 生物标志物研究
背景情况:
- 俯卧 (PP) 是急性呼吸窘迫综合征 (ARDS) 的关键干预措施,改善气体交换和呼吸机械.
- 它的应用在COVID-19大流行期间激增,突出了其临床意义.
- 目前的反应评估依赖于PaO2/FiO2比率,对PP期间生物标志物动态的数据有限.
研究的目的:
- 审查中度至重度ARDS生物标志物的临床相关性,包括COVID-19和非COVID-19病因.
- 研究PP对ARDS患者生物标志物调节的影响.
- 确定可能有助于预测接受PPPP的ARDS患者的结果的生物标志物.
主要方法:
- 对ARDS中的易感定位和生物标志物研究的系统文献综述.
- 分析PP的生理基础,包括通风再分配和减轻压力/应变.
- 在不同的ARDS阶段和表型中探索生物标志物行为.
主要成果:
- 在中度至重度的ARDS中,PP显著影响气体交换和临床结果.
- 关于PP期间特定生物标志物如何变化的数据有限.
- 生物标志物在预测PP期间ARDS预后中的作用需要进一步调查.
结论:
- 在ARDS中PP期间的生物标志物跟踪提供了超出PaO2/FiO2比率的精细结果预测的潜力.
- 需要进一步研究以阐明ARDS患者治疗PP的生物标志物的动态变化和预后价值.
- 了解PP对生物标志物调节的理解可以个性化ARDS管理.
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