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Autoimmune Disorders01:29

Autoimmune Disorders

442
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
442
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

1.5K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.5K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

955
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
955
The Thyroid Gland01:23

The Thyroid Gland

3.9K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.9K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K

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Updated: Jul 5, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

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系统性硬化症中的甲状腺疾病:综合性审查

Aifer Cherim1,2, Răzvan-Cosmin Petca3,4, Mihai-Cristian Dumitrascu5,6

  • 1Department of Dermatovenerology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Journal of clinical medicine
|January 23, 2024
PubMed
概括

系统性硬化症 (硬化皮质) 与增加的甲状腺疾病有关,包括甲状腺功能低下和甲状腺功能过高,特别是在女性中. 甲状腺自身免疫标记物在硬化肌病患者中更为常见,影响疾病预后.

关键词:
这是家族性自身免疫.系统性硬化症 系统性硬化症甲状腺癌是一种癌症.甲状腺疾病 甲状腺疾病

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Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

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相关实验视频

Last Updated: Jul 5, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Published on: June 16, 2020

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Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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科学领域:

  • 风湿病学和内分泌学.
  • 自身免疫性疾病 研究 研究 研究

背景情况:

  • 系统性硬化症 (硬皮症) 是一种慢性自身免疫性疾病,影响皮肤和器官.
  • 它主要影响女性,并且可以与甲状腺疾病同时发生.
  • 疲劳和体重变化等症状在全身性硬化症和甲状腺疾病之间重叠.

研究的目的:

  • 综合审查甲状腺疾病与全身性硬化症之间的关系.
  • 使用PubMed来源的研究分析2002-2022年间的证据.

主要方法:

  • 对21项原始研究进行了系统分析.
  • 包括32,285名患者的数据.
  • 文献综述,重点关注甲状腺功能障碍和全身性硬化症标志物.

主要成果:

  • 在全身性硬化症患者,尤其是女性中,提升的TSH水平和甲状腺功能低下更为常见.
  • 甲状腺功能障碍的发生在全身性硬化症中增加,对预后产生负面影响.
  • 在全身性硬化症中观察到甲状腺抗体 (抗TPO) 和自身免疫疾病的更高患病率.

结论:

  • 系统性硬化症与甲状腺功能障碍和特定自身抗体的发病率较高有关.
  • 甲状腺疾病可能会影响全身性硬化症的预后,需要临床关注.
  • 需要进一步的研究来澄清复杂的相互作用和临床影响.