成年人的自身免疫多分泌综合征 意大利乳病患者
Dante Pio Pallotta1, Alessandro Granito1,2, Alberto Raiteri1
1Unit of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Journal of clinical medicine
|January 23, 2024
概括
结核病 (CD) 经常与自身免疫内分泌疾病 (AED) 发生,包括自身免疫甲状腺炎和1型糖尿病. 2型自身免疫多分泌综合征是CD患者罕见但重要的发现.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
背景情况:
- 结核病 (CD) 经常与自身免疫性疾病有关.
- 以前的研究集中在单个自身免疫内分泌疾病 (AEDs) 的CD上,如自身免疫甲状腺炎 (AIT) 和1型糖尿病 (T1DM).
- 作为自身免疫多分泌综合征 (APS) 的一部分,CD的数据有限.
研究的目的:
- 为了调查孤立的AEDs和APS在成人乳病患者的大量队列中的流行率.
- 了解CD诊断和相关的AED之间的时间关系.
- 突出ACS在CD患者中的重要性,并为查策略提供信息.
主要方法:
- 分析了从920名成年CD患者中前性收集的数据.
- 包括2013年至2023年间在意大利第三级中心诊断的患者.
- 收集关于孤立的AED和APS的流行情况的数据.
主要成果:
- 28.5%的CD患者至少有一种相关的AED.
- 自免疫性甲状腺炎 (24.2%) 和1型糖尿病 (2.9%) 是最常见的AED.
- 1.4%的患者符合2型自身免疫多分泌综合征 (APS-2) 的标准.
- 在66%的病例中,AED在CD后被诊断出来.
- 虽然很少见,但APS-2在意大利CD患者中是一种显著的并发症.
结论:
- 病患者有明显的相关自身免疫内分泌疾病的患病率.
- 2型自身免疫多分泌综合征是CD患者罕见但重要的考虑因素.
- 建议CD患者定期查甲状腺功能障碍和高血糖症.
- 在T1DM和其他AED患者中,对CD的系统查至关重要.
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