三聚类药物输送系统,一种现代的关节炎向治疗方法
Célia Faustino1, Noélia Duarte1, Lídia Pinheiro1
1Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Avenida Prof. Gama Pinto, 1649-003 Lisbon, Portugal.
Pharmaceuticals (Basel, Switzerland)
|January 23, 2024
概括
天然的三类药物在关节炎治疗中表现有前途,但其生物利用性较差. 纳米载体药物递送系统 (DDS) 通过改善三类药理动力学并使向性关节炎治疗成为可能,提供了一个解决方案.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物运输 药物运输 药物运输
- 自然产品 自然产品
背景情况:
- 关节炎是导致残疾的主要原因,如疾病修饰性抗风湿药物 (DMARDs) 等当前的治疗方法在长期使用时存在风险.
- 具有抗炎作用的天然化合物 - - 三聚胺在临床前关节炎模型中表现出有效性,但面临生物可用性挑战 (溶解性低,代谢快).
研究的目的:
- 审查基于纳米载体的药物递送系统 (DDSs) 以增强关节炎中的三类药物治疗.
- 在过去十年中,探索纳米载体DDS治疗骨关节炎 (OA),类风湿性关节炎 (RA) 和痛风的进展.
主要方法:
- 在过去十年中发表的研究的文献综述.
- 专注于纳米载体DDS,包括聚合物纳米粒子,微粒,脂质体,纳米乳液和水凝.
- 对用于关节炎治疗的三类输送系统的分析.
主要成果:
- 已经开发出各种纳米载体DDS (聚合物纳米颗粒,小粒,脂质体,纳米乳液,水凝) 用于三烯酸的输送.
- 这些DDS改善了三二的药物动力学概况,并使药物持续释放成为可能.
- 纳米载体系统在关节炎模型中显示出优越的治疗效果,与自由三相比,其安全性与现有药物相比.
结论:
- 纳米载体DDS是提供抗关节炎三类药物的有效替代品,克服生物可用性限制.
- 这些先进的系统为各种形式的关节炎提供了有针对性的交付和改善的治疗结果.
- 对纳米载体DDS的进一步研究为开发更安全,更有效的关节炎治疗提供了显著的潜力.
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