成人和老年精神分裂症患者的抗精神病药物和死亡率
Ling-Ling Yeh1, Wei-Chen Lee2, Kuei-Hong Kuo3,4
1Graduate School of Humanities and Social Sciences, Dharma Drum Institute of Liberal Arts, New Taipei City 208, Taiwan.
Pharmaceuticals (Basel, Switzerland)
|January 23, 2024
概括
精神分裂症患者使用抗精神病药物与死亡风险有关. 低到中度暴露可能是有益的,但高暴露,特别是老年人,增加死亡风险.
科学领域:
- 精神病学是一个精神病学.
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 精神分裂症患者面临高死亡风险,而抗精神病药物的作用尚不清楚.
- 由于社会老龄化,精神分裂症的老年人需要特别注意.
研究的目的:
- 研究抗精神病药物剂量与精神分裂症患者死亡率之间的关联.
- 分析这些关联,特别是在精神分裂症患者的老年亚组中.
主要方法:
- 利用台湾国家健康保险研究数据库 (2010-2014).
- 包括102,964名精神分裂症患者和6,433名老年精神分裂症患者.
- 雇佣的年龄和性别匹配的对照组进行比较.
主要成果:
- 在精神分裂症患者中,没有抗精神病药物暴露显示出最高的整体和心血管死亡风险.
- 与没有或高暴露相比,低到中度的抗精神病药物暴露与较低的死亡率有关.
- 高度抗精神病药物暴露与老年精神分裂症患者的最高死亡风险相关.
结论:
- 抗精神病剂的使用可以对精神分裂症患者在低到中等暴露水平有好处.
- 在老年精神分裂症患者中,临床医生必须谨慎使用高剂量的抗精神病药物.
- 剂量管理对于减轻精神分裂症治疗中的死亡风险至关重要.
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