长期抗发作药物对人类血液中氧化素参数的影响
Danijel Jakovljević1,2, Milan Nikolić1, Vesna Jovanović1
1Department of Biochemistry, Faculty of Chemistry, University of Belgrade, 11158 Belgrade, Serbia.
Pharmaceuticals (Basel, Switzerland)
|January 23, 2024
概括
抗发作药物改变了氧化还原平衡. 拉莫特里金和卡巴马泽平在患者中显著改变了抗氧化酶配置文件,影响了超氧化物转化酶,催化酶和亚酸盐水平.
科学领域:
- 生物化学 生化学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 影响全球数以百万计的人,但抗发作药物的对氧化还原平衡的影响仍然不太清楚.
- 氧化还原稳定在细胞功能和疾病发病过程中起着至关重要的作用.
研究的目的:
- 为了比较单独治疗拉莫特里金,卡巴马西平和氨酸对患者的氧化还原平衡的长期影响.
- 研究红细胞和血中抗氧化酶和氧化应激标记物的变化.
主要方法:
- 对抗氧化酶 (超氧化脱酶,酸酶,谷氨过氧化酶,谷氨减少酶) 和相关标记物 (血红蛋白,甲血红蛋白,总蛋白质,硫醇,酸盐,脂类过氧化物,总谷氨) 的分析.
- 在单一治疗 (lamotrigine,carbamazepine,valproate) 的患者和未经药物治疗的对照人群之间的比较.
- 使用正规差异分析来区分酶配置文件.
主要成果:
- 拉莫特里金治疗降低了超氧化物脱酶活性和醇和脂质过氧化物总度.
- 卡巴马泽平治疗增加了亚酸盐水平,并降低了超氧化物失调酶活性.
- 瓦尔酸盐治疗导致酶活性降低. 红细胞抗氧化酶的组成在拉莫特里金/卡巴马西平组和对照组之间有显著差异.
结论:
- 用抗发作药物的单疗法明显改变了氧化还原稳态.
- 特定的抗发作药物诱导抗氧化酶配置和氧化还原平衡的独特变化.
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