可降解的聚合物生物 (纳米) 材料及其生物医学应用:全面概述和最近的更新
Ketan Kuperkar1, Leonard Ionut Atanase2,3, Anita Bahadur4
1Department of Chemistry, Sardar Vallabhbhai National Institute of Technology (SVNIT), Ichchhanath, Piplod, Surat 395007, Gujarat, India.
Polymers
|January 23, 2024
概括
可降解聚合物为生物医学用途提供生物相容,低成本的解决方案. 本综述涵盖了天然和合成聚合物,它们的修饰,以及在药物输送和组织工程中的应用.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 纳米技术 纳米技术
背景情况:
- 可降解聚合物在生物医学应用中越来越重要,因为它们具有良好的特性,如生物相容性和低成本.
- 天然聚合物 (多糖,蛋白质) 和合成聚合物 (聚,聚胺等). 它们是关键材料.
研究的目的:
- 为生物医学应用提供天然和合成可降解聚合物的最新概述.
- 描述各种聚合物改性技术及其对材料性能的影响.
- 突出这些先进的聚合物系统所面临的生物医学应用和挑战.
主要方法:
- 关于自然和合成可降解聚合物的文献综述.
- 聚合物修饰策略的描述:交叉链接,聚合物,纳米复合材料,功能化,共聚物.
- 对聚合物纳米粒子的降解机制,药物负载和毒理学的分析.
主要成果:
- 详细介绍各种多糖,蛋白质和合成聚合物 (聚,聚氨酸,聚化物,聚酸,聚酸,聚氨,聚氨).
- 阐明转换方法,包括交叉链接,聚合物,纳米复合材料和共聚合.
- 定义降解机制,药物负载,以及由此产生的纳米颗粒的毒理特征.
结论:
- 可降解聚合物是用于伤口愈合,生物传感器,药物输送,组织工程和再生医学的多功能生物材料.
- 聚合物修饰技术提高了材料性能,以满足特定的生物医学需求.
- 基于可降解聚合物的纳米系统显示出克服当前药物输送挑战的巨大潜力.
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